The origin of a disease and the origin of metabolic changes—often lies in the cellular processes of the tissue. To characterize metabolic changes underlying a disease phenotype, it is advantageous to analyze metabolite concentrations in tissue samples of animal models or human biopsy samples. Lipids are an important component of tissues, so studying lipid metabolism changes in tissues can can provide unique information on physiological or pathological mechanisms elucidation and biomarker discovery. Here are some related studys. lipidomic analysis of brain tissue https://lipidomics.creative-proteomics.com/tissues-untargeted-lipidomics.htm